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Hypoxia-induced autophagy is inhibited by PADI4 knockdown, which promotes apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis

Impaired apoptosis of rheumatoid arthritis (RA)-fibroblast-like synoviocytes (FLS) is pivotal in the process of RA. Peptidyl arginine deiminase type IV (PADI4) is associated with autoantibody regulation via histone citrullination in RA. The present study aimed to investigate the role of PADI4 in the...

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Foilsithe in:Mol Med Rep
Main Authors: Fan, Tingting, Zhang, Changsong, Zong, Ming, Fan, Lieying
Formáid: Artigo
Teanga:Inglês
Foilsithe: D.A. Spandidos 2018
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865976/
https://ncbi.nlm.nih.gov/pubmed/29393388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3892/mmr.2018.8501
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