PADI4 Epigenetically Suppresses p21 Transcription and Inhibits Cell Apoptosis in Fibroblast-like Synoviocytes from Rheumatoid Arthritis Patients

Rheumatoid arthritis (RA) is characterized by synovial lining hyperplasia, which involves abnormal growth of fibroblast-like synoviocytes (FLSs). This study aimed to investigate the function and molecular mechanism of peptidylarginine deiminase type 4 (PADI4) in FLSs isolated from RA patients (RA-FL...

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Detalhes bibliográficos
Publicado no:Int J Biol Sci
Main Authors: Fan, Lieying, Zong, Ming, Gong, Ruhan, He, Dongyi, Li, Niu, Sun, Li shan, Ye, Qin, Yu, Shanshan
Formato: Artigo
Idioma:Inglês
Publicado em: Ivyspring International Publisher 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5370443/
https://ncbi.nlm.nih.gov/pubmed/28367100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7150/ijbs.16879
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