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Preclinical characterization of therapeutic antibodies targeted at the carboxy-terminus of Sonic hedgehog
The Sonic Hedgehog (Shh) signaling pathway has been implicated in the development and tumor progression of a number of human cancers. Using synthetic peptide mimics to mount an immune response, we generated a mouse mAb to the carboxy (C)-terminus of the Shh protein and characterized its preclinical...
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| Publicat a: | Oncotarget |
|---|---|
| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Impact Journals LLC
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5865672/ https://ncbi.nlm.nih.gov/pubmed/29581846 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24510 |
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