Membrane-bound full-length Sonic Hedgehog identifies cancer stem cells in human non-small cell lung cancer

The mechanism of Sonic Hedgehog (Shh) pathway activation in non-small cell lung cancer (NSCLC) is poorly described. Using an antibody against the Shh C-terminal domain, we found a small population of Shh-positive (Shh+) cells in NSCLC cells. The objective of this study was to characterize these Shh+...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Giroux Leprieur, Etienne, Tolani, Bhairavi, Li, Hui, Leguay, Fleur, Hoang, Ngoc T., Acevedo, Luis A., Jin, Joy Q., Tseng, Hsin-Hui, Yue, Dongsheng, Kim, Il-Jin, Wislez, Marie, Wang, Changli, Jablons, David M., He, Biao
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2017
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5732763/
https://ncbi.nlm.nih.gov/pubmed/29262597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.21781
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