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HDAC8 substrates identified by genetically-encoded active site photocrosslinking
The histone deacetylase family comprises 18 enzymes that catalyze deacetylation of acetylated lysine residues, however, the specificity and substrate profile of each enzyme remains largely unknown. Due to transient enzyme-substrate interactions, conventional co-immunoprecipitation methods frequently...
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| Publicado no: | J Am Chem Soc |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5865639/ https://ncbi.nlm.nih.gov/pubmed/29035536 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.7b07603 |
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