HDAC8 substrate selectivity is determined by long- and short-range interactions leading to enhanced reactivity for full-length histone substrates compared with peptides

Histone deacetylases (HDACs) catalyze deacetylation of acetyl-lysine residues within proteins. To date, HDAC substrate specificity and selectivity have been largely estimated using peptide substrates. However, it is unclear whether peptide substrates accurately reflect the substrate selectivity of H...

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Bibliografiske detaljer
Udgivet i:J Biol Chem
Main Authors: Castañeda, Carol Ann, Wolfson, Noah A., Leng, Katherine R., Kuo, Yin-Ming, Andrews, Andrew J., Fierke, Carol A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Biochemistry and Molecular Biology 2017
Fag:
Enzymology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5766737/
https://ncbi.nlm.nih.gov/pubmed/29109148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M117.811026
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