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The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability
INTRODUCTION: Toltrazuril (Tol) is used to prevent and combat coccidiosis. However, its low aqueous solubility and poor oral bioavailability limit clinical application. METHODS: To overcome the shortcomings, toltrazuril–hydroxypropyl–β-cyclodextrin inclusion complex (Tol-HP-β-CD) was prepared and ch...
Gespeichert in:
| Veröffentlicht in: | Drug Des Devel Ther |
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| Hauptverfasser: | , , , , , , , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Dove Medical Press
2018
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5865576/ https://ncbi.nlm.nih.gov/pubmed/29593381 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S157611 |
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