The hydroxypropyl–β-cyclodextrin complexation of toltrazuril for enhancing bioavailability

INTRODUCTION: Toltrazuril (Tol) is used to prevent and combat coccidiosis. However, its low aqueous solubility and poor oral bioavailability limit clinical application. METHODS: To overcome the shortcomings, toltrazuril–hydroxypropyl–β-cyclodextrin inclusion complex (Tol-HP-β-CD) was prepared and ch...

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Bibliografiske detaljer
Udgivet i:Drug Des Devel Ther
Main Authors: Zhang, Li, Liu, Mengxi, Lu, Chaocheng, Ren, Dandan, Fan, Guoqing, Liu, Chang, Liu, Mengjiao, Shu, Gang, Peng, Guangneng, Yuan, Zhixiang, Zhong, Zhijun, Zhang, Wei, Fu, Hualin
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2018
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865576/
https://ncbi.nlm.nih.gov/pubmed/29593381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S157611
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