Dexmedetomidine attenuates lung apoptosis induced by renal ischemia–reperfusion injury through α(2)AR/PI3K/Akt pathway

BACKGROUND: Acute lung injury caused by renal ischemia–reperfusion is one of the leading causes of acute kidney injury-related death. Dexmedetomidine, an α(2)-adrenergic agonist sedative, has been found to have protective effects against acute kidney injury and remote lung injury. We sought to deter...

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Veröffentlicht in:J Transl Med
Hauptverfasser: Li, Juanjuan, Chen, Qian, He, Xinhai, Alam, Azeem, Ning, Jiaolin, Yi, Bin, Lu, Kaizhi, Gu, Jianteng
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2018
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865375/
https://ncbi.nlm.nih.gov/pubmed/29566706
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-018-1455-1
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