Adenoviral Type 35 and 26 Vectors with a Bidirectional Expression Cassette in the E1 Region Show an Improved Genetic Stability Profile and Potent Transgene-Specific Immune Response

Genetic vaccines based on replication-incompetent adenoviral (AdV) vectors are currently in clinical development. Monovalent AdV vectors express one antigen from an expression cassette placed in most cases in the E1 region. For many vaccines, inclusion of several antigens is necessary in order to ra...

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Udgivet i:Hum Gene Ther
Main Authors: Vujadinovic, Marija, Wunderlich, Kerstin, Callendret, Benoit, Koning, Marina, Vermeulen, Mark, Sanders, Barbara, van der Helm, Esmeralda, Gecgel, Adile, Spek, Dirk, de Boer, Karin, Stalknecht, Masha, Serroyen, Jan, Grazia Pau, Maria, Schuitemaker, Hanneke, Zahn, Roland, Custers, Jerome, Vellinga, Jort
Format: Artigo
Sprog:Inglês
Udgivet: Mary Ann Liebert, Inc. 2018
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865256/
https://ncbi.nlm.nih.gov/pubmed/28816084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.023
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