Adenoviral Type 35 and 26 Vectors with a Bidirectional Expression Cassette in the E1 Region Show an Improved Genetic Stability Profile and Potent Transgene-Specific Immune Response

Genetic vaccines based on replication-incompetent adenoviral (AdV) vectors are currently in clinical development. Monovalent AdV vectors express one antigen from an expression cassette placed in most cases in the E1 region. For many vaccines, inclusion of several antigens is necessary in order to ra...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Hum Gene Ther
Autori principali: Vujadinovic, Marija, Wunderlich, Kerstin, Callendret, Benoit, Koning, Marina, Vermeulen, Mark, Sanders, Barbara, van der Helm, Esmeralda, Gecgel, Adile, Spek, Dirk, de Boer, Karin, Stalknecht, Masha, Serroyen, Jan, Grazia Pau, Maria, Schuitemaker, Hanneke, Zahn, Roland, Custers, Jerome, Vellinga, Jort
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2018
Soggetti:
Research Articles
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865256/
https://ncbi.nlm.nih.gov/pubmed/28816084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2017.023
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