Measurable residual disease detection by high-throughput sequencing improves risk stratification for pediatric B-ALL

Early response to induction chemotherapy is an important prognostic factor in B-lymphoblastic leukemia (B-ALL). Here, we compare high-throughput sequencing (HTS) of IGH and TRG genes vs flow cytometry (FC) for measurable residual disease (MRD) detection at the end of induction chemotherapy in pediat...

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Vydáno v:Blood
Hlavní autoři: Wood, Brent, Wu, David, Crossley, Beryl, Dai, Yunfeng, Williamson, David, Gawad, Charles, Borowitz, Michael J., Devidas, Meenakshi, Maloney, Kelly W., Larsen, Eric, Winick, Naomi, Raetz, Elizabeth, Carroll, William L., Hunger, Stephen P., Loh, Mignon L., Robins, Harlan, Kirsch, Ilan
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Lymphoid Neoplasia
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865233/
https://ncbi.nlm.nih.gov/pubmed/29284596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-09-806521
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