Targeting anticoagulant protein S to improve hemostasis in hemophilia

Improved treatments are needed for hemophilia A and B, bleeding disorders affecting 400 000 people worldwide. We investigated whether targeting protein S could promote hemostasis in hemophilia by rebalancing coagulation. Protein S (PS) is an anticoagulant acting as cofactor for activated protein C a...

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Vydáno v:Blood
Hlavní autoři: Prince, Raja, Bologna, Luca, Manetti, Mirko, Melchiorre, Daniela, Rosa, Irene, Dewarrat, Natacha, Suardi, Silvia, Amini, Poorya, Fernández, José A., Burnier, Laurent, Quarroz, Claudia, Reina Caro, Maria Desiré, Matsumura, Yasuhiro, Kremer Hovinga, Johanna A., Griffin, John H., Simon, Hans-Uwe, Ibba-Manneschi, Lidia, Saller, François, Calzavarini, Sara, Angelillo-Scherrer, Anne
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2018
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865230/
https://ncbi.nlm.nih.gov/pubmed/29317453
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2017-09-800326
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