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Untargeted metabolomics reveals a new mode of action of pretomanid (PA-824)
Pretomanid is a promising anti-tubercular drug currently at clinical phase III, but its mechanisms of action are currently unclear. This study aimed to: (i) reveal the metabolome of Mycobacterium smegmatis under pretomanid treatment; (ii) compare major sources of metabolite variation in bacteria tre...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5865180/ https://ncbi.nlm.nih.gov/pubmed/29572459 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-23110-1 |
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