Genetic variation in Aquaporin-4 moderates the relationship between sleep and brain Aβ-amyloid burden

The glymphatic system is postulated to be a mechanism of brain Aβ-amyloid clearance and to be most effective during sleep. Ablation of the astrocytic end-feet expressed water-channel protein, Aquaporin-4, in mice, results in impairment of this clearance mechanism and increased brain Aβ-amyloid depos...

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Veröffentlicht in:Transl Psychiatry
Hauptverfasser: Rainey-Smith, Stephanie R., Mazzucchelli, Gavin N., Villemagne, Victor L., Brown, Belinda M., Porter, Tenielle, Weinborn, Michael, Bucks, Romola S., Milicic, Lidija, Sohrabi, Hamid R., Taddei, Kevin, Ames, David, Maruff, Paul, Masters, Colin L., Rowe, Christopher C., Salvado, Olivier, Martins, Ralph N., Laws, Simon M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865132/
https://ncbi.nlm.nih.gov/pubmed/29479071
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41398-018-0094-x
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