A loop region of BAFF controls B cell survival and regulates recognition by different inhibitors

The B cell survival factor (TNFSF13B/BAFF) is often elevated in autoimmune diseases and is targeted in the clinic for the treatment of systemic lupus erythematosus. BAFF contains a loop region designated the flap, which is dispensable for receptor binding. Here we show that the flap of BAFF has two...

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Publicado no:Nat Commun
Main Authors: Vigolo, Michele, Chambers, Melissa G., Willen, Laure, Chevalley, Dehlia, Maskos, Klaus, Lammens, Alfred, Tardivel, Aubry, Das, Dolon, Kowalczyk-Quintas, Christine, Schuepbach-Mallepell, Sonia, Smulski, Cristian R., Eslami, Mahya, Rolink, Antonius, Hummler, Edith, Samy, Eileen, Fomekong Nanfack, Yves, Mackay, Fabienne, Liao, Maofu, Hess, Henry, Jiang, Xuliang, Schneider, Pascal
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865128/
https://ncbi.nlm.nih.gov/pubmed/29572442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03323-8
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