Stoichiometry of Heteromeric BAFF and APRIL Cytokines Dictates Their Receptor Binding and Signaling Properties

The closely related TNF family ligands B cell activation factor (BAFF) and a proliferation-inducing ligand (APRIL) serve in the generation and maintenance of mature B-lymphocytes. Both BAFF and APRIL assemble as homotrimers that bind and activate several receptors that they partially share. However,...

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Dades bibliogràfiques
Publicat a:J Biol Chem
Autors principals: Schuepbach-Mallepell, Sonia, Das, Dolon, Willen, Laure, Vigolo, Michele, Tardivel, Aubry, Lebon, Luc, Kowalczyk-Quintas, Christine, Nys, Josquin, Smulski, Cristian, Zheng, Timothy S., Maskos, Klaus, Lammens, Alfred, Jiang, Xuliang, Hess, Henry, Tan, Seng-Lai, Schneider, Pascal
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2015
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4481231/
https://ncbi.nlm.nih.gov/pubmed/25953898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.661405
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