Natural and Vaccine-Induced Acquisition of Cross-Reactive IgG-Inhibiting ICAM-1-Specific Binding of a Plasmodium falciparum PfEMP1 Subtype Associated Specifically with Cerebral Malaria

Cerebral malaria (CM) is a potentially deadly outcome of Plasmodium falciparum malaria that is precipitated by sequestration of infected erythrocytes (IEs) in the brain. The adhesion of IEs to brain endothelial cells is mediated by a subtype of parasite-encoded erythrocyte membrane protein 1 (PfEMP1...

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Veröffentlicht in:Infect Immun
Hauptverfasser: Olsen, Rebecca W., Ecklu-Mensah, Gertrude, Bengtsson, Anja, Ofori, Michael F., Lusingu, John P. A., Castberg, Filip C., Hviid, Lars, Adams, Yvonne, Jensen, Anja T. R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2018
Schlagworte:
Host Response and Inflammation
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865037/
https://ncbi.nlm.nih.gov/pubmed/29426042
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00622-17
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