Dot/Icm-Translocated Proteins Important for Biogenesis of the Coxiella burnetii-Containing Vacuole Identified by Screening of an Effector Mutant Sublibrary

Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-derived vacuole. A determinant necessary for C. burnetii virulence is the Dot/Icm type IVB secretion system (T4SS). The Dot/Icm system delivers more than 100 proteins, called type IV effectors (T4Es), across the vacuolar me...

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Detalhes bibliográficos
Publicado no:Infect Immun
Main Authors: Crabill, Emerson, Schofield, Whitman B., Newton, Hayley J., Goodman, Andrew L., Roy, Craig R.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2018
Assuntos:
Cellular Microbiology: Pathogen-Host Cell Molecular Interactions
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5865027/
https://ncbi.nlm.nih.gov/pubmed/29339460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00758-17
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