A Screen of Coxiella burnetii Mutants Reveals Important Roles for Dot/Icm Effectors and Host Autophagy in Vacuole Biogenesis

Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-derived vacuole. The molecular mechanisms used by this bacterium to create a pathogen-occupied vacuole remain largely unknown. Here, we conducted a visual screen on an arrayed library of C. burnetii NMII transposon insertio...

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Detalhes bibliográficos
Main Authors: Newton, Hayley J., Kohler, Lara J., McDonough, Justin A., Temoche-Diaz, Morayma, Crabill, Emerson, Hartland, Elizabeth L., Roy, Craig R.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4117601/
https://ncbi.nlm.nih.gov/pubmed/25080348
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004286
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