Guanabenz promotes neuronal survival via enhancement of ATF4 and parkin expression in models of Parkinson disease

Reduced function of parkin appears to be a central pathogenic event in Parkinson disease (PD). Increasing parkin levels enhances survival in models of PD-related neuronal death and is a promising therapeutic objective. Previously, we demonstrated that the transcription factor ATF4 promotes survival...

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Publicado en:Exp Neurol
Main Authors: Sun, Xiaotian, Aimé, Pascaline, Dai, David, Ramalingam, Nagendran, Crary, John F., Burke, Robert E., Greene, Lloyd A., Levy, Oren A.
Formato: Artigo
Idioma:Inglês
Publicado: 2018
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864566/
https://ncbi.nlm.nih.gov/pubmed/29432724
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2018.01.015
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