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Redox-dependent BMI1 activity drives in vivo adult cardiac progenitor cell differentiation

Accumulation of reactive oxygen species (ROS) is associated with several cardiovascular pathologies and with cell cycle exit by neonanatal cardiomyocytes, a key limiting factor in the regenerative capacity of the adult mammalian heart. The polycomb complex component BMI1 is linked to adult progenito...

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Publicat a:Cell Death Differ
Autors principals: Herrero, Diego, Tomé, María, Cañón, Susana, Cruz, Francisco M., Carmona, Rosa María, Fuster, Encarna, Roche, Enrique, Bernad, Antonio
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2018
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864208/
https://ncbi.nlm.nih.gov/pubmed/29323265
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0022-2
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