Diacylglycerol triggers Rim101 pathway–dependent necrosis in yeast: a model for lipotoxicity

The loss of lipid homeostasis can lead to lipid overload and is associated with a variety of disease states. However, little is known as to how the disruption of lipid regulation or lipid overload affects cell survival. In this study we investigated how excess diacylglycerol (DG), a cardinal metabol...

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Veröffentlicht in:Cell Death Differ
Hauptverfasser: Rockenfeller, Patrick, Smolnig, Martin, Diessl, Jutta, Bashir, Mina, Schmiedhofer, Vera, Knittelfelder, Oskar, Ring, Julia, Franz, Joakim, Foessl, Ines, Khan, Muhammad J., Rost, René, Graier, Wolfgang F., Kroemer, Guido, Zimmermann, Andreas, Carmona-Gutierrez, Didac, Eisenberg, Tobias, Büttner, Sabrina, Sigrist, Stephan J., Kühnlein, Ronald P., Kohlwein, Sepp D., Gourlay, Campbell W., Madeo, Frank
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2017
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864183/
https://ncbi.nlm.nih.gov/pubmed/29230001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0014-2
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