Diacylglycerol triggers Rim101 pathway–dependent necrosis in yeast: a model for lipotoxicity

The loss of lipid homeostasis can lead to lipid overload and is associated with a variety of disease states. However, little is known as to how the disruption of lipid regulation or lipid overload affects cell survival. In this study we investigated how excess diacylglycerol (DG), a cardinal metabol...

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Publicado no:Cell Death Differ
Main Authors: Rockenfeller, Patrick, Smolnig, Martin, Diessl, Jutta, Bashir, Mina, Schmiedhofer, Vera, Knittelfelder, Oskar, Ring, Julia, Franz, Joakim, Foessl, Ines, Khan, Muhammad J., Rost, René, Graier, Wolfgang F., Kroemer, Guido, Zimmermann, Andreas, Carmona-Gutierrez, Didac, Eisenberg, Tobias, Büttner, Sabrina, Sigrist, Stephan J., Kühnlein, Ronald P., Kohlwein, Sepp D., Gourlay, Campbell W., Madeo, Frank
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5864183/
https://ncbi.nlm.nih.gov/pubmed/29230001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-017-0014-2
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