Two key cathepsins, TgCPB and TgCPL, are targeted by the vinyl sulfone inhibitor K11777 in in vitro and in vivo models of toxoplasmosis

Although toxoplasmosis is one of the most common parasitic infections worldwide, therapeutic options remain limited. Cathepsins, proteases that play key roles in the pathogenesis of toxoplasmosis and many other protozoan infections, are important potential therapeutic targets. Because both TgCPB and...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chaparro, Juan D., Cheng, Timmy, Tran, Uyen Phuong, Andrade, Rosa M., Brenner, Sara B. T., Hwang, Grace, Cohn, Shara, Hirata, Ken, McKerrow, James H., Reed, Sharon L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2018
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863946/
https://ncbi.nlm.nih.gov/pubmed/29565998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0193982
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