Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

BACKGROUND: Effects of methotrexate (MTX) on the proliferation of rheumatoid arthritis (RA) synovial fibroblasts are incompletely understood. We explored actions of MTX in view of circadian transcriptions of synovial fibroblasts. METHODS: Under treatment with MTX, expression of core circadian clock...

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Pubblicato in:Arthritis Res Ther
Autori principali: Suzuki, Kohjin, Yoshida, Kohsuke, Ueha, Takeshi, Kaneshiro, Kenta, Nakai, Ayako, Hashimoto, Naonori, Uchida, Koto, Hashimoto, Teppei, Kawasaki, Yoshiko, Shibanuma, Nao, Nakagawa, Natsuko, Sakai, Yoshitada, Hashiramoto, Akira
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863822/
https://ncbi.nlm.nih.gov/pubmed/29566767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13075-018-1552-9
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