Analysis of the expression pattern of the schizophrenia-risk and intellectual disability gene TCF4 in the developing and adult brain suggests a role in development and plasticity of cortical and hippocampal neurons

BACKGROUND: Haploinsufficiency of the class I bHLH transcription factor TCF4 causes Pitt-Hopkins syndrome (PTHS), a severe neurodevelopmental disorder, while common variants in the TCF4 gene have been identified as susceptibility factors for schizophrenia. It remains largely unknown, which brain reg...

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Dettagli Bibliografici
Pubblicato in:Mol Autism
Autori principali: Jung, Matthias, Häberle, Benjamin M., Tschaikowsky, Tristan, Wittmann, Marie-Theres, Balta, Elli-Anna, Stadler, Vivien-Charlott, Zweier, Christiane, Dörfler, Arnd, Gloeckner, Christian Johannes, Lie, D. Chichung
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863811/
https://ncbi.nlm.nih.gov/pubmed/29588831
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-018-0200-1
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