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Observing enzyme ternary transition state analogue complexes by (19)F NMR spectroscopy

Ternary transition state analogue (TSA) complexes probing the isomerization of β-d-glucose 1-phosphate (G1P) into d-glucose 6-phosphate (G6P) catalyzed by catalytically active, fluorinated (5-fluorotryptophan), β-phosphoglucomutase (βPGM) have been observed directly by (19)F NMR spectroscopy. In the...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Ampaw, Anna, Carroll, Madison, von Velsen, Jill, Bhattasali, Debabrata, Cohen, Alejandro, Bowler, Matthew W., Jakeman, David L.
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863612/
https://ncbi.nlm.nih.gov/pubmed/29619190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c7sc04204c
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