Prime-boost BCG vaccination with DNA vaccines based in β-defensin-2 and mycobacterial antigens ESAT6 or Ag85B improve protection in a tuberculosis experimental model

The World Health Organization (WHO) has estimated that there are about 8 million new cases annually of active Tuberculosis (TB). Despite its irregular effectiveness (0–89%), the Bacillus Calmette-Guérin) BCG is the only vaccine available worldwide for prevention of TB; thus, the design is important...

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Veröffentlicht in:Vaccine
Hauptverfasser: Cervantes-Villagrana, Alberto R., Hernández-Pando, Rogelio, Biragyn, Arya, Castañeda-Delgado, Julio, Bodogai, Monica, Martínez-Fierro, Margarita, Sada, Eduardo, Trujillo, Valentin, Enciso-Moreno, Antonio, Rivas-Santiago, Bruno
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5863248/
https://ncbi.nlm.nih.gov/pubmed/23196205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2012.11.042
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