Strong radioprotective FGF1 signaling down-regulates proliferative and metastatic capabilities of the angiosarcoma cell line, ISOS-1, through the dual inhibition of EGFR and VEGFR pathways

BACKGROUND AND PURPOSE: Angiosarcoma is associated with a poor prognosis and is treated with radiotherapy. Although FGF1 is a potential radioprotector, the influence of FGF1 on the malignancy of angiosarcoma remains unknown. MATERIALS AND METHODS: Highly stable FGF1 mutants, which exhibit stronger m...

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Pubblicato in:Clin Transl Radiat Oncol
Autori principali: Miura, Taichi, Fujita, Mayumi, Kawano, Mitsuko, Imadome, Kaori, Yasuda, Takeshi, Nishihara, Shoko, Imamura, Toru, Masuzawa, Mikio, Imai, Takashi, Nakayama, Fumiaki
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2017
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862641/
https://ncbi.nlm.nih.gov/pubmed/29594234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ctro.2017.10.006
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