Cardiac glycoside bufalin blocks cancer cell growth by inhibition of Aurora A and Aurora B activation via PI3K-Akt pathway

In our previous study, cardiac glycosides including bufalin, a group of sodium pump (Na+/K+-ATPase) inhibitors widely used to treat heart failure for many years, have been demonstrated to induce a delay of mitotic entry and mitotic arrest in many cancer cells. However, the underlying mechanism remai...

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Detalhes bibliográficos
Publicado no:Oncotarget
Main Authors: Xie, Chuan-Ming, Lin, Xiao-Tong, Wu, Di, Tan, Ye, Cheng, Christopher H.K., Zhang, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862615/
https://ncbi.nlm.nih.gov/pubmed/29568394
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.24475
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