Broken replication forks trigger heritable DNA breaks in the terminus of a circular chromosome

It was recently reported that the recBC mutants of Escherichia coli, deficient for DNA double-strand break (DSB) repair, have a decreased copy number of their terminus region. We previously showed that this deficit resulted from DNA loss after post-replicative breakage of one of the two sister-chrom...

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Veröffentlicht in:PLoS Genet
Hauptverfasser: Sinha, Anurag Kumar, Possoz, Christophe, Durand, Adeline, Desfontaines, Jean-Michel, Barre, François-Xavier, Leach, David R. F., Michel, Bénédicte
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862497/
https://ncbi.nlm.nih.gov/pubmed/29522563
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1007256
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