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STAT3 Gene Silencing by Aptamer-siRNA Chimera as Selective Therapeutic for Glioblastoma

Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor in adults, and despite advances in neuro-oncology, the prognosis for patients remains dismal. The signal transducer and activator of transcription-3 (STAT3) has been reported as a key regulator of the highly aggressive mesenc...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Esposito, Carla Lucia, Nuzzo, Silvia, Catuogno, Silvia, Romano, Simona, de Nigris, Filomena, de Franciscis, Vittorio
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862137/
https://ncbi.nlm.nih.gov/pubmed/29499951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2017.12.021
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