Functional variants in HCN4 and CACNA1H may contribute to genetic generalized epilepsy

OBJECTIVE: Genetic generalized epilepsy (GGE) encompasses seizure disorders characterized by spike‐and‐wave discharges (SWD) originating within thalamo‐cortical circuits. Hyperpolarization‐activated (HCN) and T‐type Ca(2+) channels are key modulators of rhythmic activity in these brain regions. Here...

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Detalhes bibliográficos
Publicado no:Epilepsia Open
Main Authors: Becker, Felicitas, Reid, Christopher A., Hallmann, Kerstin, Tae, Han‐Shen, Phillips, A. Marie, Teodorescu, Georgeta, Weber, Yvonne G., Kleefuss‐Lie, Ailing, Elger, Christian, Perez‐Reyes, Edward, Petrou, Steven, Kunz, Wolfram S., Lerche, Holger, Maljevic, Snezana
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2017
Assuntos:
Full‐length Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862120/
https://ncbi.nlm.nih.gov/pubmed/29588962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/epi4.12068
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