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Phenytoin as a last‐resort treatment in SCN8A encephalopathy
SCN8A encodes Nav1.6, one of the main voltage‐gated sodium channel subunits in the brain, and SCN8A mutations lead to epileptic encephalopathy. Particular mutations render the mutant channel more susceptible to inhibition by phenytoin. Yet, the potentially severe side effects of phenytoin maintenanc...
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| Publicado no: | Epilepsia Open |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5862112/ https://ncbi.nlm.nih.gov/pubmed/29588963 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/epi4.12059 |
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