Inhibition of ERK1/2 or AKT Activity Equally Enhances Radiation Sensitization in B16F10 Cells

BACKGROUND: The aim of the study was to evaluate the radiation sensitizing ability of ERK1/2, PI3K-AKT and JNK inhibitors in highly radiation resistant and metastatic B16F10 cells which carry wild-type Ras and Braf. METHODS: Mouse melanoma cell line B16F10 was exposed to 1.0, 2.0 and 3.0 Gy of elect...

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Vydáno v:World J Oncol
Hlavní autoři: Kalal, Bhuvanesh Sukhlal, Fathima, Faraz, Pai, Vinitha Ramanath, Sanjeev, Ganesh, Krishna, Chilakapati Murali, Upadhya, Dinesh
Médium: Artigo
Jazyk:Inglês
Vydáno: Elmer Press 2018
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5862079/
https://ncbi.nlm.nih.gov/pubmed/29581812
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.14740/wjon1088w
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