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Single molecule real-time (SMRT) sequencing comes of age: applications and utilities for medical diagnostics

Short read massive parallel sequencing has emerged as a standard diagnostic tool in the medical setting. However, short read technologies have inherent limitations such as GC bias, difficulties mapping to repetitive elements, trouble discriminating paralogous sequences, and difficulties in phasing a...

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Bibliografiske detaljer
Udgivet i:Nucleic Acids Res
Main Authors: Ardui, Simon, Ameur, Adam, Vermeesch, Joris R, Hestand, Matthew S
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2018
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861413/
https://ncbi.nlm.nih.gov/pubmed/29401301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gky066
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