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Can Interactions Between α-Synuclein, Dopamine and Calcium Explain Selective Neurodegeneration in Parkinson's Disease?

Several lines of evidence place alpha-synuclein (aSyn) at the center of Parkinson's disease (PD) etiology, but it is still unclear why overexpression or mutated forms of this protein affect some neuronal populations more than others. Susceptible neuronal populations in PD, dopaminergic neurons...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Front Neurosci
Hauptverfasser: Post, Michael R., Lieberman, Ori J., Mosharov, Eugene V.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5861202/
https://ncbi.nlm.nih.gov/pubmed/29593491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnins.2018.00161
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