The sixth transmembrane segment is a major gating component of the TMEM16A calcium-activated chloride channel

Calcium-activated chloride channels (CaCC) formed by TMEM16A or TMEM16B are broadly expressed in the nervous system, smooth muscles, exocrine glands, and other tissues. With two calcium-binding sites and a pore within each monomer, the dimeric CaCC exhibits voltage dependent calcium sensitivity. Cha...

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Veröffentlicht in:Neuron
Hauptverfasser: Peters, Christian J., Gilchrist, John M., Tien, Jason, Bethel, Neville P., Qi, Lijun, Chen, Tingxu, Wang, Lynn, Jan, Yuh Nung, Grabe, Michael, Jan, Lily Y.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860880/
https://ncbi.nlm.nih.gov/pubmed/29478917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuron.2018.01.048
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