Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts. The dengue virus 2 (DENV2) - encoded protease cleaves human STING, reducing typ...

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Pubblicato in:eLife
Autori principali: Stabell, Alex C, Meyerson, Nicholas R, Gullberg, Rebekah C, Gilchrist, Alison R, Webb, Kristofor J, Old, William M, Perera, Rushika, Sawyer, Sara L
Natura: Artigo
Lingua:Inglês
Pubblicazione: eLife Sciences Publications, Ltd 2018
Soggetti:
Microbiology and Infectious Disease
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860865/
https://ncbi.nlm.nih.gov/pubmed/29557779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31919
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