Dengue viruses cleave STING in humans but not in nonhuman primates, their presumed natural reservoir

Human dengue viruses emerged from primate reservoirs, yet paradoxically dengue does not reach high titers in primate models. This presents a unique opportunity to examine the genetics of spillover versus reservoir hosts. The dengue virus 2 (DENV2) - encoded protease cleaves human STING, reducing typ...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Stabell, Alex C, Meyerson, Nicholas R, Gullberg, Rebekah C, Gilchrist, Alison R, Webb, Kristofor J, Old, William M, Perera, Rushika, Sawyer, Sara L
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2018
Assuntos:
Microbiology and Infectious Disease
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860865/
https://ncbi.nlm.nih.gov/pubmed/29557779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31919
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