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Amino Acid Substitutions of Coiled-Coil Protein Tpr Abrogate Anchorage to the Nuclear Pore Complex but Not Parallel, In-Register Homodimerization

Tpr is a protein component of nuclear pore complex (NPC)-attached intranuclear filaments. Secondary structure predictions suggest a bipartite structure, with a large N-terminal domain dominated by heptad repeats (HRs) typical for coiled-coil–forming proteins. Proposed functions for Tpr have included...

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Bibliografische gegevens
Hoofdauteurs: Hase, Manuela E., Kuznetsov, Nikolai V., Cordes, Volker C.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Cell Biology 2001
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC58605/
https://ncbi.nlm.nih.gov/pubmed/11514627
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