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β-Cell Inactivation of Gpr119 Unmasks Incretin Dependence of GPR119-Mediated Glucoregulation
GPR119 was originally identified as an orphan β-cell receptor; however, subsequent studies demonstrated that GPR119 also regulates β-cell function indirectly through incretin hormone secretion. We assessed the importance of GPR119 for β-cell function in Gpr119(−/−) mice and in newly generated Gpr119...
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| Publicado en: | Diabetes |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
American Diabetes Association
2017
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5860191/ https://ncbi.nlm.nih.gov/pubmed/28254842 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db17-0017 |
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