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GateKeeper: a new hardware architecture for accelerating pre-alignment in DNA short read mapping

MOTIVATION: High throughput DNA sequencing (HTS) technologies generate an excessive number of small DNA segments -called short reads- that cause significant computational burden. To analyze the entire genome, each of the billions of short reads must be mapped to a reference genome based on the simil...

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Vydáno v:Bioinformatics
Hlavní autoři: Alser, Mohammed, Hassan, Hasan, Xin, Hongyi, Ergin, Oğuz, Mutlu, Onur, Alkan, Can
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2017
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860160/
https://ncbi.nlm.nih.gov/pubmed/28575161
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btx342
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