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biMM: efficient estimation of genetic variances and covariances for cohorts with high-dimensional phenotype measurements

SUMMARY: Genetic research utilizes a decomposition of trait variances and covariances into genetic and environmental parts. Our software package biMM is a computationally efficient implementation of a bivariate linear mixed model for settings where hundreds of traits have been measured on partially...

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Detalhes bibliográficos
Publicado no:Bioinformatics
Main Authors: Pirinen, Matti, Benner, Christian, Marttinen, Pekka, Järvelin, Marjo-Riitta, Rivas, Manuel A, Ripatti, Samuli
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860115/
https://ncbi.nlm.nih.gov/pubmed/28369165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btx166
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