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Estimating error models for whole genome sequencing using mixtures of Dirichlet-multinomial distributions

MOTIVATION: Accurate identification of genotypes is an essential part of the analysis of genomic data, including in identification of sequence polymorphisms, linking mutations with disease and determining mutation rates. Biological and technical processes that adversely affect genotyping include cop...

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Bibliografske podrobnosti
izdano v:Bioinformatics
Main Authors: Wu, Steven H, Schwartz, Rachel S, Winter, David J, Conrad, Donald F, Cartwright, Reed A
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2017
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5860108/
https://ncbi.nlm.nih.gov/pubmed/28334373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btx133
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