Accurate control of dual-receptor-engineered T cell activity through a bifunctional anti-angiogenic peptide

BACKGROUND: Chimeric antigen receptors (CARs) presented on T cell surfaces enable redirection of T cell specificity, which has enormous promise in antitumor therapy. However, excessive activity and poor control over such engineered T cells cause significant safety challenges, such as cytokine releas...

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Detalhes bibliográficos
Publicado no:J Hematol Oncol
Main Authors: Zhang, Erhao, Gu, Jieyi, Xue, Jianpeng, Lin, Chenyu, Liu, Chen, Li, Mengwei, Hao, Jingchao, Setrerrahmane, Sarra, Chi, Xiaowei, Qi, Weiyan, Hu, Jialiang, Xu, Hanmei
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2018
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859748/
https://ncbi.nlm.nih.gov/pubmed/29558951
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-018-0591-7
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