BRD7 expression and c-Myc activation forms a double-negative feedback loop that controls the cell proliferation and tumor growth of nasopharyngeal carcinoma by targeting oncogenic miR-141

BACKGROUND: miR-141 is up-regulated and plays crucial roles in nasopharyngeal carcinoma (NPC). However, the molecular mechanism underlying the dysregulation of miR-141 is still obscure. METHODS: Thus, the ChIP-PCR was performed to identify the c-Myc-binding sites in miR-141 and BRD7. qRT-PCR, wester...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:J Exp Clin Cancer Res
Autori principali: Liu, Yukun, Zhao, Ran, Wei, Yanmei, Li, Mengna, Wang, Heran, Niu, Weihong, Zhou, Yao, Qiu, Yuanzheng, Fan, Songqing, Zhan, Yihao, Xiong, Wei, Zhou, Yanhong, Li, Xiaoling, Li, Zheng, Li, Guiyuan, Zhou, Ming
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2018
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859396/
https://ncbi.nlm.nih.gov/pubmed/29559001
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-018-0734-2
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