Pharmacological inhibition of AKT activity in human CD34(+) cells enhances their ability to engraft immunodeficient mice

Although practiced clinically for more than 40 years, the use of hematopoietic stem cell (HSC) transplantation remains limited by the inability to expand functional HSCs ex vivo. To determine the role of phosphoinositide 3-kinase (PI3K)/AKT signaling in human hematopoietic stem and progenitor cell (...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Exp Hematol
Prif Awduron: Chen, Sisi, Gao, Rui, Kobayashi, Michihiro, Yu, Hao, Yao, Chonghua, Kapur, Reuben, Yoder, Mervin C., Liu, Yan
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2016
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859321/
https://ncbi.nlm.nih.gov/pubmed/27645691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.exphem.2016.09.003
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