Successful knock-in of Hypertrophic Cardiomyopathy-mutation R723G into the MYH7 gene mimics HCM pathology in pigs

Familial Hypertrophic Cardiomyopathy (HCM) is the most common inherited cardiac disease. About 30% of the patients are heterozygous for mutations in the MYH7 gene encoding the ß-myosin heavy chain (MyHC). Hallmarks of HCM are cardiomyocyte disarray and hypertrophy of the left ventricle, the symptoms...

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Bibliografske podrobnosti
izdano v:Sci Rep
Main Authors: Montag, J., Petersen, B., Flögel, A. K., Becker, E., Lucas-Hahn, A., Cost, G. J., Mühlfeld, C., Kraft, T., Niemann, H., Brenner, B.
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2018
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5859159/
https://ncbi.nlm.nih.gov/pubmed/29555974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-018-22936-z
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