Integrated Molecular Analysis of Tamoxifen-Resistant Invasive Lobular Breast Cancer Cells Identifies MAPK and GRM/mGluR Signaling as Therapeutic Vulnerabilities

Invasive lobular breast cancer (ILC) is an understudied malignancy with distinct clinical, pathological, and molecular features that distinguish it from the more common invasive ductal carcinoma (IDC). Mounting evidence suggests that estrogen receptor-alpha positive (ER+) ILC has a poor response to...

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Udgivet i:Mol Cell Endocrinol
Main Authors: Stires, Hillary, Heckler, Mary M., Fu, Xiaoyong, Zhao, Li, Grasso, Catherine S., Quist, Michael J., Lewis, Joseph A., Klimach, Uwe, Zwart, Alan, Mahajan, Akanksha, Győrffy, Balázs, Cavalli, Luciane R., Riggins, Rebecca B.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5858970/
https://ncbi.nlm.nih.gov/pubmed/28935545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mce.2017.09.024
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